Since Casimir Funk first described “vital amines” in 1912, we have seen major improvements in
public health through sizable reductions of then commonplace deficiencies. Yet over 100 years
later deficiencies in a multitude of macro- and micronutrients (e.g. Vitamin D, E, Omega-3 fatty
acids) remain highly prevalent in the general United States population....
These nutritional deficiencies have been found to raise the risk for a wide
array of health outcomes including the leading causes of death
(i.e. cardiovascular diseases, malignant neoplasms, diabetes, and cerebrovascular diseases).3-10
Therefore, addressing them is of vital importance to continue to build on the progress
we have made thus far, but we also need to move beyond just preventing
deficiencies toward the optimization of health and performance for each individual.
This dossier will lay out the current state of nutrient intakes in the US, its consequences for human health,
and how moving to objective measurements of nutrient status coupled with customized
dietary supplement protocols will enable individuals to not just avoid deficiencies,
but optimize intake for maximal fitness and well-being.
The key to effective personalized nutrient supplements is an integrated cycle of measurement. We help you remeasure every three months so you can chart changes and improvements to your well-being. Choosing Baze makes optimizing your body seamless and simple.
Meet our scientific advisory board. A group of pioneers and elite practitioners at the cusp of nutritional science. Our members help guide the scientific direction of Baze. They advise us on the latest techniques, clinical studies, and ongoing research.
Prof. Eran Segal
Lutz Graumann, MD
10 Year Head of Nutrition
Dr. Joshua M. Kotfila
Rutgers, Cal State, Institute
of Environmental Medicine
BUT WHICH TEST?
Place it on your upper arm and press the green button. It’s as simple as that. Once the button is pressed wait for the indicator to turn red and you’re done!
- Developed at MIT
- Convenient handling
- Indicator window shows you when it’s ready
- 100uL whole blood
- Lithium heparin
- 1.5 inches in diameter
- Single-use - microneedles are secured in device
The product is currently only available if you participate in our user research study on your experience with the sample collection device.
While a range of factors impact your wellbeing, Baze focuses on the important impact your micronutrient levels have on these areas of your life.
Bones & Joint
Bones and joints are passive structures in our body. They are structural components that carry all of our muscles and organs. Bones and especially joints are also essential for every movement of our body and yet diseases of those structures are not uncommon.
Impact of nutrition on bones and joints
It’s commonly known that calcium and vitamin D are important for healthy bones 1. However, bone development also depends on certain hormones, such as Estrogen, Testosterone, Calcitonin and Growth Hormone 2. Levels of some of those hormones are dropping with age and therefore, humans can build bone matter only up to a certain age.
Bone loss with age
Older and elderly people are unable to increase their bone mineral density and that’s the reason why you should do your best to strengthen your bones while you can.
To combat bone loss from aging (Osteoporosis), you should pay attention to related nutrients. Bones act as storage for minerals, such as calcium and magnesium. If the body needs those minerals elsewhere, it takes it from its storage, so you should keep a constant supply in order to prevent from losses. Furthermore, Vitamin D is crucial for mineral uptake from the intestine and incorporation in bone matter.
Impact of lifestyle
Several other lifestyle factors play a role in prevention and delaying osteoporosis, including physical activity, alcohol consumption and sunlight exposure. 3, 4
Talking about age, many older people also suffer from aching joints as well. Several diseases and conditions can cause this type of symptoms, such as arthritis, rheumatism or tendonitis. Proper nutrition and supplementation (e.g. Vitamin E and Omega-3 fatty Acids) can lower inflammation and therefore decrease and prevent from joint pain. 5
1 Ross, A.C., Taylor, C.L., Yaktine, A.L. and Del Valle, H.B. eds., 2011. Dietary reference intakes for calcium and vitamin D. National Academies Press.
2 Paller, C.J., Shiels, M.S., Rohrmann, S., Basaria, S., Rifai, N., Nelson, W., Platz, E.A. and Dobs, A., 2009. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology, 70(1), pp.26-34.
3 Weaver, C.M., Gordon, C.M., Janz, K.F., Kalkwarf, H.J., Lappe, J.M., Lewis, R., O’Karma, M., Wallace, T.C. and Zemel, B.S., 2016. The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporosis International, 27(4), pp.1281-1386.
4 Levis, S. and Lagari, V.S., 2012. The role of diet in osteoporosis prevention and management. Current osteoporosis reports, 10(4), pp.296-302.
5 Norling, L.V. and Perretti, M., 2013. The role of omega-3 derived resolvins in arthritis. Current opinion in pharmacology, 13(3), pp.476-481.
Segmented into a number of distinct yet related abilities, such as perception, memory, attention, motor skills, executive functions such as decision-making, our vital “Brain” is an indicator of overall mental health and quality of life. It marks the extent to which your cognitive abilities allow you to carry out any task, from the simplest to the most complex.
The many impacts of brain functioning
Poor brain function may impair a variety of cognitive tasks, such as quick and logical thinking, simple or complex movements requiring spatial processing and coordination, problem-solving and decision-making
The aging brain
People tend to experience a certain level of cognitive decline as they age, but for some, the decline is more noticeable and can affect overall health and quality of life. For some, Mild Cognitive Impairment (MCI) may further deteriorate and lead to Alzheimer’s Disease or dementia 1. While there are multiple contributing factors to cognitive decline, including stress, loneliness, and excess body weight, suboptimal nutrition in combination with chronic inflammation and oxidative stress may play a role in the onset of cognitive decline 2. For example, Omega-3 Fatty acids are a structural component of brain tissue and deficiency is related to poor brain function and accelerated brain aging 3.
1 Janoutová, J., Serý, O., Hosák, L. and Janout, V., 2015. Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review. Central European journal of public health, 23(4), p.365.
2 Huskisson, E., Maggini, S. and Ruf, M., 2007. The influence of micronutrients on cognitive function and performance. Journal of international medical research, 35(1), pp.1-19.
3 Denis, I., Potier, B., Heberden, C. and Vancassel, S., 2015. Omega-3 polyunsaturated fatty acids and brain aging. Current Opinion in Clinical Nutrition & Metabolic Care, 18(2), pp.139-146.
A key component of energy provision in the body is Adenosine Triphosphate (ATP). In order to get used by every single cell, our macronutrients have to be converted into this molecule. Therefore, ATP is called “the ultimate source of energy” in the human body. ATP stores and transfers energy between cells, and when it breaks down into Adenosine Diphosphate (ADP) and Phosphate, it liberates energy necessary for all metabolic and physiological processes.
Your body’s many uses of energy
When you’re physically active, your muscles use a lot of energy. But you’d be surprised how much energy our brain and other organs demand for optimal functioning. Our brain, liver, heart and kidneys make up 70-80% of our Resting Energy Expenditure (REE), whereas muscles and adipose (aka body fat) tissue only expend smaller amounts of energy during physical inactivity 1. When we eat, our intestines also require a fair amount of energy to break down and absorb the nutrients we eat. So regardless of your activity levels, your body’s energy stores are critical to how well you function.
How nutrients contribute
Several micronutrients are involved in producing ATP from the macronutrients your body gets access to. Vitamins and minerals are necessary for activating enzymes, biological catalysts that execute all metabolic processes in the body. By optimizing your nutrient status, you can also optimize your energy supply in order to fuel your ambitions. 2
1 Aragon, A.A., Schoenfeld, B.J., Wildman, R., Kleiner, S., VanDusseldorp, T., Taylor, L., Earnest, C.P., Arciero, P.J., Wilborn, C., Kalman, D.S. and Stout, J.R., 2017. International society of sports nutrition position stand: diets and body composition. Journal of the International Society of Sports Nutrition, 14(1), p.16.
2 Huskisson, E., Maggini, S. and Ruf, M., 2007. The role of vitamins and minerals in energy metabolism and well-being. Journal of international medical research, 35(3), pp.277-289.
Hair, Skin, & Nails
Skin, hair and nails are factors that influence your outward appearance. Interestingly, our skin, hair and nails are outward indicators of our intrinsic health and from an evolutionary standpoint serve as an indicator of fertility, health and genetic material. Therefore, we still choose our mates instinctively based on these outward characteristics, at least partially.1
Increasing inflammation along with the decreased ability of our immune system to ward off foreign invaders makes us more susceptible not just to disease, but to changes in our physical makeup as well. The accumulation of oxidative stress throughout the lifespan, and the subsequent damage to cells and DNA, is another contributing factor to changing physical appearance. 2, 3
But other than the onset of age-related disease, what are some of these changes we so often worry about? Wrinkles, thinning skin, changing skin color and thickness, loss of muscle tone, shrinking jaws, and many others, are changes that commonly occur as we get older or not getting proper nutrients. But it’s important to remember that although these changes are natural products of aging, they can also be caused by disease states we may be able to control. We can also certainly postpone the onset of these changes if we make the appropriate lifestyle choices, including following a balanced macronutrient (carbs, protein, fats) and micronutrient (vitamins, minerals) intake. 4, 5
1 Samson, N., Fink, B. and Matts, P.J., 2010. Visible skin condition and perception of human facial appearance. International Journal of Cosmetic Science, 32(3), pp.167-184.
2 Rinnerthaler, M., Bischof, J., Streubel, M.K., Trost, A. and Richter, K., 2015. Oxidative stress in aging human skin. Biomolecules, 5(2), pp.545-589.
3 Trüeb, R.M., 2015. The impact of oxidative stress on hair. International journal of cosmetic science, 37(S2), pp.25-30.
4 Trüeb, R.M., 2015. Effect of ultraviolet radiation, smoking and nutrition on hair. In Alopecias-Practical Evaluation and Management (Vol. 47, pp. 107-120). Karger Publishers.
5 Pappas, A., Liakou, A. and Zouboulis, C.C., 2016. Nutrition and skin. Reviews in Endocrine and Metabolic Disorders, 17(3), pp.443-448.
As an integrated system of cells, tissues, and organs, the immune system protects the body against infection and disease.
Specifically, the immune system fights against bacteria, viruses and fungi. It must recognize foreign invaders and abnormal cells to generate the immune response, sometimes in the form of inflammation. For this reason, the immune system can be a double-edged sword, as inflammation can cause damage to tissues while fighting against foreign invaders.
Nutrition and Immunity
Given that nutritional status can affect the actions of the immune system, it is not surprising that immunology and nutrition are tightly connected. Malnutrition is the most common cause of immunodeficiency in the world, and chronic malnutrition one of the leading causes of death. But malnutrition is not the only factor affecting immune function. Poor overall nutrition can lead to micronutrient deficiencies, such as zinc, magnesium and vitamin D, that may compromise immune system function, making nutrition an important aspect of maintaining a healthy immune system. 1, 2
1 Calder, P.C., 2013. Feeding the immune system. Proceedings of the Nutrition Society, 72(3), pp.299-309.
2 Katona, P. and Katona-Apte, J., 2008. The interaction between nutrition and infection. Clinical Infectious Diseases, 46(10), pp.1582-1588.
Libido & Fertility
Fertility and Libido are both wholly separate and deeply interrelated aspects of our lives. Without a sexual urge, we’re not motivated to have sex and produce healthy offspring. But without proper Fertility, we don’t provide the necessary seeds and breeding ground to procreate either.
Unlike the rest of our vitals, the nutrients that contribute to male and female fertility and libido are actually quite different – especially in terms of the contributions of omega-3. Given the nutrients, we currently measure we are able to provide scores for male fertility and libido and female fertility.
All of our vitals exclusively refer to yourself, with one exception. By “Female Fertility”, we’re not only referring to your ability to get pregnant, but also the ability to give birth to a healthy child. If you are looking to get pregnant, you should optimize your nutritional status beforehand. Your nutrition and lifestyle directly impact the health of your child because it depends on the nutrients that are available to them. This phase of life is very crucial for the development of a child's brain and other characteristics which are fundamental for its whole life.
For example, studies have shown that low Omega-3 status before, during pregnancy, and while breastfeeding impairs the cognitive development of the child’s brain and leads to lower mental development later in life. If you're looking to start a healthy family, you should take care of your nutrient status even before you get pregnant! 1,2,3
Male Fertility & Libido
dsa The primary male sex hormone is testosterone. This hormone is crucial for the development of typical primary and secondary male characteristics, such as the development of sex organs, increased muscle mass and facial hair growth, as well as fertility and sex drive (libido).
We know that testosterone levels rise with puberty and slowly decline with age. Therefore, fertility and libido can also decrease as we get older. We can combat this natural decline by impacting nutrient deficiencies which can also cause low testosterone levels and impair fertility and libido. With proper nutrient intake, age-related decline of testosterone levels can be hampered and prevent from early onset of these changes. 4,5
1 Fontana, R. and Torre, S.D., 2016. The deep correlation between energy metabolism and reproduction: a view on the effects of nutrition for women fertility. Nutrients, 8(2), p.87.
2 Bernardi, J.R., Escobar, R.D.S., Ferreira, C.F. and Silveira, P.P., 2012. Fetal and neonatal levels of omega-3: effects on neurodevelopment, nutrition, and growth. The Scientific World Journal, 2012.
3 Christian, P., Mullany, L.C., Hurley, K.M., Katz, J. and Black, R.E., 2015, August. Nutrition and maternal, neonatal, and child health. In Seminars in perinatology (Vol. 39, No. 5, pp. 361-372). WB Saunders.
4 Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., Wehr, E. and Zittermann, A., 2011. Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43(03), pp.223-225.
5 Colagar, A.H., Marzony, E.T. and Chaichi, M.J., 2009. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutrition Research, 29(2), pp.82-88
We all want to live a long, healthy life. In order to do so, we want to minimize cellular damage and prevent diseases that would impair our quality of life or even shorten it.
Cellular Aging and Free Radicals
As you age during adulthood, all your cells, tissues, and organs undergo aging changes, and all vital organs lose some of their function. Many changes take place during adulthood that are likely involved in the process of cellular aging. Scientists are still searching for an underlying process that may be responsible for these different changes. Although they’ve yet to reach full agreement, it seems that the process of oxidative stress, or “free radical” damage to DNA, may be the culprit.
What’s important to understand is that sometimes, these changes to aging cells can be so pronounced as to potentially cause the onset of age-related diseases, from osteoporosis to Alzheimer’s. Sustained oxidative stress during adulthood may even trigger the early onset of age-related physical and cognitive decline. 1, 2, 3
The Heart and Arteries
The health of your heart and arteries is also crucial for a long and good life. Cardiovascular Disease (CVD), a condition that develops as a result of fatty plaque buildup on arterial walls, can lead to life-threatening events like heart attack and stroke. While some people may be genetically predisposed to CVD, most people suffer from the disease due to reversible lifestyle factors like smoking, being overweight and sedentary, as well as consuming too much alcohol. What’s more, we can do a lot to prevent CDV by ingesting enough Omega-3 fatty acids, B-Vitamins and other micronutrients to have a healthy heart and a good life! 4, 5
1 Zeliger, H.I., 2016. Predicting disease onset in clinically healthy people. Interdisciplinary Toxicology, 9(2), pp.39-54.
2 Revel, F., Gilbert, T., Roche, S., Drai, J., Blond, E., Ecochard, R. and Bonnefoy, M., 2015. Influence of oxidative stress biomarkers on cognitive decline. Journal of Alzheimer's Disease, 45(2), pp.553-560.
3 Zhou, Q., Zhu, L., Zhang, D., Li, N., Li, Q., Dai, P., Mao, Y., Li, X., Ma, J. and Huang, S., 2016. Oxidative stress-related biomarkers in postmenopausal osteoporosis: a systematic review and meta-analyses. Disease markers, 2016.
4 Superko, H.R., Superko, A.R., Lundberg, G.P., Margolis, B., Garrett, B.C., Nasir, K. and Agatston, A.S., 2014. Omega-3 fatty acid blood levels clinical significance update. Current cardiovascular risk reports, 8(11), pp.1-8.
5 Debreceni, B. and Debreceni, L., 2014. The Role of Homocysteine‐Lowering B‐Vitamins in the Primary Prevention of Cardiovascular Disease. Cardiovascular therapeutics, 32(3), pp.130-138.
Sleep & Stress
Sleep is that golden chain that ties health and our bodies together. - Thomas Dekker (1572–1632), Elizabethan poet and dramatist
There is so much truth in this proverb. Getting a good amount of rest at night is essential for the human body. During this time we’re not only recovering physically but also mentally. But that does not mean that our brain is inactive during that time. It is processing all the information that is received during the day so that it can store it in our memory.1 Maybe you’ve experienced it yourself, after a good amount of sleep, your mind is rearranged and thoughts are clearer. That’s why we prefer to make decisions after sleeping on it a night.
Chronic sleep deprivation can not only cause fatigue, tiredness, clumsiness and weight loss or weight gain, it also adversely affects the brain and cognitive function.2 So it’s advised to get at least 6 to 8 hours of quality sleep per night.
However, the quality and quantity of sleep can be impaired by nutrient deficiencies and surpluses. For example, fixing a vitamin D deficiency has been shown to improve sleep quality3, but high blood values may even impair subjective sleep quality. You may optimize your nightly rest period by optimizing your nutrient status.4
The link between stress and sleep
We’re living in a fast-paced society and a lot of people are suffering from mental and/or physical stress because of that. However, a well-balanced nutrition and sensible supplementation can help you to cope with increased stress in order to make your day-to-day life easier and prevent from sleepless nights and burn-out.
Stress is directly linked to sleep because a healthy sleep helps us to recover from stressors, like high work demand, social stress, and high physical activity. Too much stress also impairs our sleep by the inability to calm down our body and mind. So these two aspects go hand in hand when it comes to optimizing them. 5
1 Rasch, B. and Born, J., 2013. About Sleep9s Role in Memory. Physiological reviews, 93(2), pp.681-766.
2 Goel, N., Basner, M., Rao, H. and Dinges, D.F., 2013. Circadian rhythms, sleep deprivation, and human performance. Progress in molecular biology and translational science, 119, p.155.
3 de Oliveira, D.L., Hirotsu, C., Tufik, S. and Andersen, M.L., 2017. The interfaces between vitamin D, sleep and pain. Journal of Endocrinology, 234(1), pp.R23-R36.
4 Boyle, N.B., Lawton, C. and Dye, L., 2017. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients, 9(5), p.429.
5 Irish, L.A., Kline, C.E., Gunn, H.E., Buysse, D.J. and Hall, M.H., 2015. The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep medicine reviews, 22, pp.23-36.
Strength & Endurance
The body requires energy to perform any movement or activity, including all metabolic processes such as muscle contraction, food digestion, brain and nerve function, etc.
Athletes and physically active people are always looking to improve their exercise performance. For this purpose, not only energy is required but also optimal recovery from training. Therefore, nutrients involved in energy production, such as B-Vitamins and magnesium are considered in this vital as well as also elements that increase exercise recovery to make you perform at your best.3
Often a sign of age-related physical decline, poor physical performance is detrimental to overall health and quality of life, as it reflects compromised muscle and/or bone function. But optimal physical performance is also a crucial factor of athletic performance. Optimal muscle and bone function may increase athletic speed performance, recovery, endurance, and strength as well. Many nutrients may boost physical performance by improving energy metabolism as well as muscle and bone function.1,2
1 Sawka, M.N., Burke, L.M., Eichner, E.R., Maughan, R.J., Montain, S.J. and Stachenfeld, N.S., 2007. American College of Sports Medicine position stand. Exercise and fluid replacement. Medicine and science in sports and exercise, 39(2), pp.377-390.
2 Dahlquist, D.T., Dieter, B.P. and Koehle, M.S., 2015. Plausible ergogenic effects of vitamin D on athletic performance and recovery. Journal of the International Society of Sports Nutrition, 12(1), p.33.
3 Huskisson, E., Maggini, S. and Ruf, M., 2007. The role of vitamins and minerals in energy metabolism and well-being. Journal of international medical research, 35(3), pp.277-289.
Our supplements are made in the USA and
tested according to the FDA’s Current Good
Manufacturing Practices, ensuring the
highest standards of potency, efficacy, and
ONLY THE BEST INGREDIENTS
Not all vitamins are created equal. For example magnesium citrate has 3 times the absorption
rate as magnesium oxide. But they both say magnesium on the bottle. All our vitamins are
selected for maximum absorption and purity, meaning you see more impact and need to take
fewer vitamins each day.
We use Vitamin D3 (Cholecalciferol), which is the form naturally produced in the body from sunlight. It has been found to be superior to Vitamin D2 in improving your nutrient levels.
We use the cyanocobalamin form of B12, which is better absorbed(1) (higher bioavailablity) and more stable than common alternative sources.
Our Omega-3 is molecularly distilled to remove environmental contaminants (including PCBs, dioxins, and mercury). They also contain 3X Omega-3 per softgel (800mg) compared to a standard fish oil from our competitors.
We use the magnesium citrate form of magnesium which has 3 times the absorption rate (bioavailablity) compared to other common forms of magnesium supplements. Plus this form been shown to have reductions in GI issues.
We use the form L-Selenomethionine, which has 90% absorption, superior than the commonly used inorganic selenium (selenite).
We use copper glycinate amino acid chelate which is a highly bioavailable form of chelated copper.
We use a combination of zinc picolinate and zinc gluconate – two highly absorbable (bioavailable) forms of zinc.
We use Natural Vitamin E. Whereas most supplements only contain Alpha Tocopherol, our product contains all 4 tocopherols in safflower oil to promote optimal absorption.
Our next-generation lab platform has been developed together with leading Swiss researchers and allows micronutrient status analysis from a 100ul blood sample. It is employed in certified labs using validated processes. In short, we get a lot from a little.
Your privacy and trust are our top priority. Your blood data is fully anonymized from the moment you drop it in the mailbox. Our nutritionists, pharmacists, and lab only interact with your data through your anonymized ID. Your vitals are your business.
Our proprietary algorithms combine your nutrient level with your lifestyle information from the app to provide the nutrient dosing which is right for you. With every new measurement they get to know your nutrient biochemistry better and adjust your dosage accordingly and drive nutrient personalization further. So you can keep track.
We use anonymized data to advance research in nutrient science and related areas. Our ambition is to uncover new pathways, biomarkers and intervention options to advance the science of health and wellbeing. We’re using data in the right way.